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Synthesis of carbon 14 labeled anti bacterial agent synthesis of carbon 14 labeled 1 ethyl 6 fluoro 1 4 dihydro 4 oxo 7 1 piperazinyl 3 quinoline carboxylic acid



Synthesis of carbon 14 labeled anti bacterial agent synthesis of carbon 14 labeled 1 ethyl 6 fluoro 1 4 dihydro 4 oxo 7 1 piperazinyl 3 quinoline carboxylic acid



Journal of Labelled Compounds & Radiopharmaceuticals 18(12): 1765-1772



1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid (AM-715), a new potent antibacterial agent, was labeled with 14C at the C-1 position of the N-ethyl group for metabolic studies. The synthesis was achieved according to 2 reaction routes. The overall radiochemical yields of 14C-AM-715 based on ethyl iodide-1-14C from route A and route B, were 29.4 and 9.4%, respectively.

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