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Synthesis of carbon 14 labeled penta methyl melamine a new anti tumor agent



Synthesis of carbon 14 labeled penta methyl melamine a new anti tumor agent



Journal of Labelled Compounds & Radiopharmaceuticals 18(7): 1009-1014



(ring-4,6-14C)Pentamethylmelamine (14C-PMM), a new antitumor agent, was prepared from barium (14C) carbonate by a 6 step synthesis. (14CN) Dimethylcyanamide, prepared from sodium (14C) cyanide with 71% yield and treated with phosgene in the presence of hydrogen chloride, was cyclized to (ring-4,6-14C)-2-chloro-4,6-bis (dimethylamino)-s-triazine. The latter was purified by silicagel low pressure liquid chromatography (15% yield based on nitrile) and condensed with monomethylamine to give 14C-PMM. After purification 14C-PMM was obtained with 91% yield, specific activity = 38 mCi/mmol. The mechanism of the reaction of nitrile with phosgene was discussed.

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Accession: 006567414

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