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Synthesis of granatanine 3 spiro 5' hydantoin n omega hydroxyalkyl esters


Synthesis of granatanine 3 spiro 5' hydantoin n omega hydroxyalkyl esters



Journal of Heterocyclic Chemistry 17(1): 103-106



ISSN/ISBN: 0022-152X

The central anticholinergic activity found in some N-.omega.-hydroxyalkylgranatanine esters I and 3-nor-granatanols N-substituted esters and the anticonvulsant activity of the hydantoin ring led to the preparation of compounds with similar structure. Synthetic methods to prepare N-.omega.-hydroxyalkyl-nor-pseudopelletierine and granatanine-3-spiro-5'-hydantoin N-.omega.-hydroxyalkylbenzylic and diphenylactic esters were analyzed. The Bucherer-Bergs synthesis used to obtain some other granatanine-spirohydantoins, originates the hydrolysis of the ester group.

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Accession: 006568511

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