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Synthesis of hexa hydro bis benzodipyrazolones hexa hydro bis benzodiazepinone and di thio pyrimidoquinazolinetetrone di ethyl 1 4 cyclo hexanedione 2 5 dicarboxylate bis aryl azo benzodipyrazolone 1 2 4 5 cyclo hexatetrone 2 5 bis aryl hydrazone hydrazine diazonium salt acid hydrazide o phenylenediamine thio urea japp klingemann reaction



Synthesis of hexa hydro bis benzodipyrazolones hexa hydro bis benzodiazepinone and di thio pyrimidoquinazolinetetrone di ethyl 1 4 cyclo hexanedione 2 5 dicarboxylate bis aryl azo benzodipyrazolone 1 2 4 5 cyclo hexatetrone 2 5 bis aryl hydrazone hydrazine diazonium salt acid hydrazide o phenylenediamine thio urea japp klingemann reaction



Zeitschrift fuer Naturforschung Teil B Anorganische Chemie Organische Chemie 34(1): 95-98



A new series of biologically active hexahydro-bis-benzodipyrazolones were obtained by the interaction of (1) [diethyl 2,4-cyclohexanedione-2,5-dicarboxylate] with hydrazines. The pyrazolones underwent coupling reaction with different diazonium salts to give bis-arylazobenzodipyrazolones. Compound 1 when treated with acid hydrazides gave 3a, b and when subjected to Japp-Klingemann reaction in alkaline medium gave 1,2,4,5-cyclohexatetrone-2,5-bis-arylhydrazones. The hexahydro-bis-benzodiazepine and dithiopyrimidoquinazolinetetrone were obtained by the interaction of 1 with o-phenylenediamine and thiourea, respectively.

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