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Synthesis of oligo nucleotides ggcctgttggc and pentadeca thymidylic acid by phospho tri ester approach using 5' p chlorophenyl esters of appropriate oligo nucleotide blocks



Synthesis of oligo nucleotides ggcctgttggc and pentadeca thymidylic acid by phospho tri ester approach using 5' p chlorophenyl esters of appropriate oligo nucleotide blocks



Bioorganicheskaya Khimiya 8(2): 224-230



The dodecanucleotide GGCCTGTTTGGC (XI) and pentadecathymidylic acid were synthesized by the phosphotriester approach using 5'-p-chlorophenyl esters of appropriate oligonucleotide blocks. The syntheses of (XI) and T(pT)14 were carried out according to the schemes [(2+2)+2] + [(2+2)+2] and [3+(3+3) + (3+3)], respectively. p-Chlorophenyl esters of N-acyl-3'-O-levulinucleoside 5'phosphates (P-component) and .beta.-cyanoethyl, p-chlorophenyl esters of N-acylnucleoside-5'-phosphates (OH-component) were used as starting compounds for the syntheses of di- and trinucleotide blocks. Toluenesulfonyltetrazole was used as a coupling reagent with OH and P components taken in equimolar ratio.

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