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Synthesis of protected deoxy ribo oligo nucleotide blocks by phospho di ester approach using 3' o methoxyacetyl protection for a nucleotide component



Synthesis of protected deoxy ribo oligo nucleotide blocks by phospho di ester approach using 3' o methoxyacetyl protection for a nucleotide component



Bioorganicheskaya Khimiya 7(3): 365-371



Condensation of 5'-cyanoethylated N-protected mono- or oligonucleotide with 3'-O-methoxyacetylated N-protected mono- or oligonucleotide in the presence of arylsulfonylchlorides, arylsulfonyltriazolides or dicyclohexylcarbodiimide followed by selective removal of methoxyacetyl group gave a 5'-cyanoethylated N-protected oligonucleotide block.

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