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Synthesis of some new 2 substituted 3 4 n' arylsulfonylbiguanidophenyl quinazolin 4 one hydro chlorides as potential anti helminthic agents



Synthesis of some new 2 substituted 3 4 n' arylsulfonylbiguanidophenyl quinazolin 4 one hydro chlorides as potential anti helminthic agents



Archiv der Pharmazie (Weinheim) 316(6): 525-529



The title compounds were synthesized. Their in vivo cestodicidal activities were evaluated against Hymenolepis nana infection in rats. 2-[3'-Nitro-4'-(N-substituted)phenyl]-3-[p-(N'-arylsulfonylbiguanido)phenyl]quinazolin-4-one hydrochloride was the most active of the series, showing 81.0% clearance of infection at a dose of 250 mg/kg for 3 days.

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