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Synthesis of tris di methylamino 2 4 6 triazine 1 3 5 carbon 14 2 4 6 hexa methyl melamine ring carbon 14 2 4 6 a new anti cancer agent



Synthesis of tris di methylamino 2 4 6 triazine 1 3 5 carbon 14 2 4 6 hexa methyl melamine ring carbon 14 2 4 6 a new anti cancer agent



Journal of Labelled Compounds and Radiopharmaceuticals 12(4): 517-522



(Ring-2,4,6-14C) Hexamethylmelamine (14C-HMM), a new antitumor agent, was prepared from 14C-urea by 2 step synthesis. 14C-Urea was cyclized in o-dichlorobenzene to (2,4,6-14C) cyanuric acid, purified by chromatography on an ion exchange Sephadex SP C-25 resin column. Direct amination of acid in the presence of HMPT [hexamethylphosphorotriamide] and dimethylamine gives 14C-HMM. After purification by silica gel adsorption column chromatography 14C-HMM was obtained with a radioactive overall yield of 18% based on 14C-urea, specific activity = 32 mCi/mmol.

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