+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Systemic and coronary hemodynamic effects of combined intravenous diltiazem and nitroglycerin administration

, : Systemic and coronary hemodynamic effects of combined intravenous diltiazem and nitroglycerin administration. American Heart Journal 113(6): 1376-1382

This study evaluated left ventricular (LV) and coronary hemodynamic effects of intravenous nitroglycerin (NTG) in the presence of an intravenous infusion of diltiazem in 15 patients with severe coronary disease. Diltiazem (250 .mu.g/kg bolus followed by 1.4 .mu.g/kg/min infusion) alone decreased mean systemic blood pressure (mean 6%) without changing heart rate or LV end-diastolic pressure. The rate of rise in LV pressure declined slightly (4%), and peripheral resistance decreased (19%). Coronary sinus (CS) and great cardiac vein (GCV) flows were preserved. Addition of NTG (average, 68 .mu.g/min) decreased systemic pressure further (7%) as LV end-diastolic pressure declined (5 mm Hg). These pressure changes were accompanied by a 10% increase in heart rate (compared with the heart rate found with diltiazem alone). Peripheral resistance was similar to values after diltiazem alone. The CS and GCV flows did not decrease. The sequence of intravenous drug administration was reversed in three patients with combination therapy, producing similar effects, regardless of which drug was administered first. Hemodynamic effects of intravenous diltiazem alone and its combination with intravenous NTG seemed potentially favorable for patients with ischemic heart disease.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006574933

PMID: 3109225

DOI: 10.1016/0002-8703(87)90651-x

Download PDF Full Text: Systemic and coronary hemodynamic effects of combined intravenous diltiazem and nitroglycerin administration

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Heiger, A.A., 1981: Complacent infantile starvation. Connecticut Medicine 45(8): 515-516

States, D.; Morange, M., 1997: The development of EMBO and EMBL A reflection of the recent history of molecular biology. M-S (Medecine Sciences) 13(3): 367-371

Vitellaro-Zuccarello, L.; Mazzetti, S.; Madaschi, L.; Bosisio, P.; Fontana, E.; Gorio, A.; D.B.asi, S., 2007: Chronic erythropoietin-mediated effects on the expression of astrocyte markers in a rat model of contusive spinal cord injury. Using a standardized rat model of contusive spinal cord injury (SCI; [Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M (2002) Recombinant human erythropoietin counteracts secondary inju...

Li, F.; Bai, H.; Li, X'nan.; Wu, M.; Yu, R.; Shi, A.; Yin, L.; Wang, J.; Zhu, G., 2012: Role of EGFR mutation status in patients with stage III non-squamous non-small cell lung cancer treated with chemoradiotherapy. The presence of epidermal growth factor receptor (EGFR) mutations is predictive of a better response to EGFR tyrosine kinase inhibitors (EGFR-TKIs) and initial chemotherapy in advanced non-squamous non-small cell lung cancer (NSCLC). The aim of th...

Czech, W., 1988: Determining blood serum level of free thyroxine based on charcoal uptake of I-131-thyroxine. Endokrynologia Polska 39(3): 143-150

Starodubov S.M.; Kurella G.A., 1973: Resting potential of salivary gland cells of drosophila larvae. Biologicheskie Nauki (Moscow) 16(9): 50-53

Harkness R.A.; Pollitt R.J.; Addison G.M., 1990: Symposium on inherited disorders of carbohydrate and glycoprotein metabolism and on maternal phenylketonuria held at the 27th annual ssiem society for the study of inborn errors of metabolism munich west germany 1989. Journal of Inherited Metabolic Disease 13(4): 395-671

Kowalski, K., 2005: Keeping participants enrolled: use of anticipation. Journal of Continuing Education in Nursing 36(1): 16-16

Khabar, K., S.A.; Siddiqui, S.; Armstrong, J., A., 1995: WEHI-13VAR: A stable and sensitive variant of WEHI 164 clone 13 fibrosarcoma for tumor necrosis factor bioassay. Bioassaying tumor necrosis factor (TNF) relies not only on a sensitive but also on a stable cell line towards TNF action. A variant of WEHI 164 clone 13, WEHI-13VAR, was characterized by us. This variant demonstrated both stability and high sensit...

Mahour, G.H.; Bryan, B.J.; Isaacs, H., 1988: Lipoblastoma and lipoblastomatosis--a report of six cases. Lipoblastoma and lipoblastomatosis are rare examples of benign mesenchymal tumors that exhibit a tendency to invade locally but not to metastasize. The tumors are found primarily in children less than 5 years of age and can arise almost anywhere w...