EurekaMag.com logo
+ Site Statistics
References:
48,252,460
Abstracts:
22,798,453
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Systemic and regional hemodynamic effects of cyclo-oxygenase and thromboxane synthetase inhibition in normal and hyperdynamic endotoxemic rabbits


, : Systemic and regional hemodynamic effects of cyclo-oxygenase and thromboxane synthetase inhibition in normal and hyperdynamic endotoxemic rabbits. Circulatory Shock 26(1): 41-57

We tested the hypothesis that prostaglandins (PGs) and thromboxane (Tx) A2 are important mediators of the hemodynamic derangements occurring in a rabbit model of hyperdynamic endotoxicosis. Rabbits were injected with either normal saline (NS) or Escherichia coli lipopolysaccharide (LPS; 1-3 micrograms/kg) and studied 6 hr later. Cardiac index (CI) and regional blood flow were determined using thermodilution and radioactive microspheres, respectively. Systemic and regional hemodynamics were determined before and 40 min after administering indomethacin (cyclo-oxygenase inhibitor; 5 mg/kg), UK38485 (Tx synthetase inhibitor; 10 mg/kg), or NS. LPS increased CI (P = .0024) and decreased mean arterial pressure (P = .0031) and systemic vascular resistance index (P = .0001). LPS increased flow to the heart and small intestine and decreased flow to the hepatic artery and pancreas. The systemic and regional hemodynamic effects of indomethacin were similar in NS- and LPS-treated rabbits. UK38485 decreased perfusion of skeletal muscle and diaphragm in both endotoxemic and control animals. This agent increased splenic perfusion only in NS-treated rabbits. Plasma levels of 6-keto PGF1 alpha (PGI2 metabolite) were typically undetectable in both NS- and LPS-treated rabbits. These data do not support the hypothesis that PG's or TxA2 are major determinants of the hemodynamic perturbations that occur in this endotoxicosis model.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006574995

PMID: 3142697

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Boettger K., 1972: Biological and ecological studies on the life cycle of fresh water mites hydrachnellae acari part 1 the life cycle of hydrachna globosa and limnochares aquatica part 2 the life cycle of limnesia maculata and unionicola crassipes. Internationale Revue der Gesamten Hydrobiologie 57(1-2): 109-152 263-319

Christiansen, T.; Rasch, R.; Flyvbjerg, A., 1995: Correlation between MRI and morphometric measurements of kidney size and cortex, medullary and pelvic volumes in control and diabetic rats. Journal of the American Society of Nephrology 6(3): 1038

Choi, Young Ho; Seng, Seyna; Toyoda, Yutaka, 1998: Effect of taurine on in vitro fertilization and embryo development of BALB/c mouse strain. Inbred BALB/c strain mouse was characterized by a low in vitro fertilization (IVF) rate. However, this strain has been used broadly for various researches, especially for researches in immunology. For improving the fertilization rate in this strai...

Dhanawansa, R.; Faridmoayer, A.; van der Merwe, G.; Li, Y.X.; Scaman, C.H., 2002: Overexpression, purification, and partial characterization of Saccharomyces cerevisiae processing alpha glucosidase I. The gene encoding yeast processing alpha glucosidase I, CWH41, was overexpressed in Saccharomyces cerevisiae AH22, resulting in a 28-fold increase in expression of the soluble form of the enzyme. The soluble enzyme results from proteolytic cleavag...

Harris, R. H., 1943: The effect of different operators on the evaluation of mixograms. Duplicate estimations by 3 operators using 10 hard red spring wheat flours diluted to a uniform protein level of 12.0% with wheat starch showed significant differences between dough development and curve height but not in dough stability. Signific...

Davies, P.J.; Parry, J.M., 1978: The modification of induced genetic change in yeast by an amino acid analogue. Treatment of diploid yeast cultures with the amino acid analogue, para-fluorophenylalanine (PFPA), at concentrations which caused inhibition of growth, resulted in up to 5 fold increases in the frequency of mitotic gene conversion at two different...

Anonymous, 1956: Symposium on Medicated Feeds, sponsored by United States Department of Health, Education, and Welfare, Food and Drug Administration, Veterinary Medical Branch, Washington, D.C., January 1956. CURTIS, J. M. (15-16), laboratory rations and the feed manufacturer's responsibilities; BYERLY, T. C. (17-27), hormones in feeds; UMBERGER, E. J. (28-31), estimation of stilboestrol residues in steer tissues; HARVEY, M. J. (32-37), antibiotic...

Pande K.; Kalsi R.; Bhalla T.N.; Barthwal J.P., 1987: Some newer imidazolones and their anti inflammatory activity. Die Pharmazie 42(4): 269

Quinones M.A.; Louria D.B.; Foster J.D.; Ledner W., 1974: Tuberculosis in newark. American Review of Respiratory Disease 109(6): 730

STRIEDER, J.W., 1946: Surgery of the heart and structures related to it. A review.