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Target cell susceptibility to immune lysis and expression of major histo compatibility complex antigens are independent of position in the cell cycle



Target cell susceptibility to immune lysis and expression of major histo compatibility complex antigens are independent of position in the cell cycle



Journal of Immunology 133(1): 40-44



The effects of progression through the mitotic cell cycle on the tumor (P815) [mouse mastocytoma] cell line's expression of H-2 antigens and susceptibility to immune cytolysis were investigated. By using a combination of DNA quantitation by Hoechst 33342 staining and fluorescence-activated cell sorter analysis, pure populations of G1, S and G2+M cells were obtained. By employing a fluorescence quenching technique utilizing bromodeoxyuridine substitution, the times required for the P815 cells to transit each of the various phases were monitored. By using mAb [monoclonal antibody] and cloned CTL [cytotoxic T lymphocyte] populations with well-defined specificities, neither H-2 antigen expression nor lytic susceptibility to mAb complement or CTL was observed to fluctuate with cell cycle progression. Each of the 3 major MHC [major histocompatibility complex] loci (H-2Kd,-Dd and -Ld) was analyzed. Expression of H-2 antigens and susceptibility to immune lysis were apparently independent of a cell's position in the cell cycle.

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Accession: 006578680

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