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Temporal relationships between ovulation and defined changes in the concentration of plasma estradiol 17 beta luteinizing hormone follicle stimulating hormone and progesterone 2. histologic dating



Temporal relationships between ovulation and defined changes in the concentration of plasma estradiol 17 beta luteinizing hormone follicle stimulating hormone and progesterone 2. histologic dating



American Journal of Obstetrics and Gynecology 139(8): 886-895



Histologic dating of the corpus luteum was used to obtain information on the time intervals between ovulation and defined changes in the concentrations of 17.beta.-estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and progesterone (P) in peripheral plasma. Women [177] were studied over the periovulatory period. Samples of peripheral blood were taken at recorded times, every 24 h on days -8 to -4 from the scheduled day of laparotomy and then every 8 h on days -3 to +2. The surfaces of both ovaries were photographed during the operation, and excision biopsy specimens were taken of the main components. The results in 78 cases in which ovulation had occurred before operation were suitable for statistical analysis. The mean time intervals (hours) from the defined hormonal events to ovulation and the 95% confidence limits of the estimates are as follows: 17.beta.-estradiol rise 96.8 (86.8-106.9), peak 41.5 (33.6-49.4); LH rise 41.0 (34.9-47.1), peak 18.4 (13.3-23.5); FSH rise 31.3 (24.9-37.8), peak 18.8 (12.9-24.8); progesterone rise 11.7 (4.9-18.5). Ovulation occurred in .apprx. 16% of women before the LH peak and 3% before the LH rise, but neither phenomenon was observed. The findings are compared with previously published data on the same temporal relationships obtained by probit analysis, using the proportion of women who had ovulated at a given time from the hormonal event. The age range of each corpus luteum was also calculated by subtracting the observed interval from the 1st significant rise of plasma LH to ovulation (24-56 h) from the time interval between the same hormonal event and operation. The morphologic changes which follow ovulation occur in an orderly sequence, but the rate will vary from woman to woman, thus making histologic dating of the corpus luteum prone to a larger error than was reported to date. Data from 120 cases showed that there was a clear relationship between the histologic dating of the mature follicle or corpus luteum and the mean concentration of estradiol and progesterone in peripheral plasma taken at the time of operation.

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Accession: 006586862

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PMID: 6784577


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