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Testicular responsiveness to long term administration of human chorionic gonadotropin and human menopausal gonadotropin in patients with hypogonadotropic hypogonadism



Testicular responsiveness to long term administration of human chorionic gonadotropin and human menopausal gonadotropin in patients with hypogonadotropic hypogonadism



Hormone Research (Basel) 23(1): 21-30



Steroidogenic responsiveness and amelioration of sperm number and motility following long-term intramuscular hCG and hMG administration were evaluated in 18 males with hypogonadotrophic hypogonadism (HH). The patients consisted of 13 patients with isolated gonadotrophin deficiency (IGD) and 5 patients hypophysectomized at an early or middle pubertal period. Basal serum levels of testosterone and 17.beta.-estradiol were within prepubertal range in all patients before the treatment. Serum testosterone levels reached the normal adult male levels within 12-24 months of the treatment in only 2 of 7 younger patients and 1 of 6 older patients with IGD, whereas in all hypophysectomized patients serum levels of both testosterone and 17.beta.-estradiol increased to the levels found in normal adult males within 6 months of the treatment. The mean peak levels of serum testosterone and 17.beta.-estradiol, respectively, during the treatment were 2.1 .+-. 0.8 (SD) ng/ml and 10.8 .+-. 4.9 (SD) pg/ml in younger patients with IGD, 1.4 .+-. 0.9 ng/ml and 9.7 .+-. 5.1 pg/ml in older patients with IGD and 6.0 .+-. 1.2 ng/ml and 34.2 .+-. 14.8 pg/ml in hypophysectomized patients. Quantitative improvement in both sperm density and sperm motility were found in 4 of 7 younger patients, 1 of 6 older patients with IGD and all hypophysectomized patients, but only 3 of hypophysectomized patients (3 of 18 patients) could become fertile.

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