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Tetrazole analogs of gamma amino butyric acid mimetic agents



Tetrazole analogs of gamma amino butyric acid mimetic agents



European Journal of Medicinal Chemistry 19(2): 181-186



Six tetrazole analogs of GABA-mimetic compounds were synthesized. In vitro, compounds 6 [(tetrazolyl-5)-4 tetrahydro-1,2,5,6 pyridine bromhydrate] showed a weak affinity for GABA-A and GABA-B receptors. In vivo these compounds were inactive in a psychopharmacological screening in mice. The results were interpreted in terms of intercharge distance, electronic delocalization and ability of membrane crossing.

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