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The 70 kilodalton mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles


The 70 kilodalton mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles



EMBO (European Molecular Biology Organization) Journal 4(13A): 3385-3392



It is shown that in immunological, structural and fucntional terms the uncoating protein, which catalyses ATP-dependent dissociation of clathrin triskelia from clathrin-coated vesicles is intimately related to two major stress proteins of mammalian cells. These proteins of hitherto unknown functions have polypeptide mol. wts. of 73 kd and 72 kd, respectively. They are normal cell constituents which are synthesized in increased abundance under adverse environmental circumstances, such as non-physiological temperatures or treatment with amino acid analogues.

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Related references

The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles. Embo Journal 4(13a): 3385-3391, 1985

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