The action of caffeine in promoting ultrastructural damage in frog skeletal muscle fibres. Evidence for the involvement of the calcium-induced release of calcium from the sarcoplasmic reticulum

Duncan, C.J.; Smith, J.L.

Naunyn-Schmiedeberg's Archives of Pharmacology 305(2): 159-166


ISSN/ISBN: 0028-1298
PMID: 310523
Accession: 006595603

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Caffine at concentrations above 5 mM caused rapidly extensive ultrastructural damage to the myofibrils of frog skeletal muscle. The effect was promoted at lower temperatures, whereas the myofibrils were protected by prior exposure to procaine. Caffeine may cause a Ca2+-induced Ca2+ release (the CROC) from the S.R. i could cause muscle damage and the possible relevance of these findings to the sequence of events in the development of myopathies of human skeletal muscle are discussed.