+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The aminergic regulation of acth secretion

The aminergic regulation of acth secretion

Actualites Pharmacologiques (28): 151-186

The complex interrelations between monoamines, such as norepinephrine, serotonin and dopamine on the activity of the anterior lobe of the pituitary, probably via hypothalamic nuclei, and the influence thereon of such drugs as reserpine, chlorpromazine, etc., is the subject of this review of the neuroendocrinological and pharmacologic literature. The emphasis is on ACTH of the anterior pituitary and on the corticotropin releasing factor (CRF) for the hypothalamus, as they are affected by catecholamines and the corticosteroids released by the adrenal glands. Much of the pharmacological work underlying this review was performed on rats and dogs. The secretion of CRF-ACTH, in the rat and probably in the dog, appears to be inhibited by noradrenergic fibers originating from cell bodies in the bulbomesencephalic region which establish axodendritic connections with the cell bodies of the peptidergic neurons secreting CRF. Norepinephrine, liberated by these fibers then exercises its inhibitory effect. In turn, certain monoamines are able to stimulate the secretion of releasing factors of the hypothalamus by acting on the gland tissue via the general circulation.

(PDF 0-2 workdays service: $29.90)

Accession: 006599087

Download citation: RISBibTeXText

Related references

Effect of ethanol on secretion of ACTH secretion in mice; studies on the mechanism of regulation of ACTH secretion. Ceskoslovenska Fysiologie 6(4): 501-506, 1957

Mono aminergic mediation of beta endorphin induced effects on acth and prolactin secretion. Clinical Research 26(6): 841A, 1978

Use of the reverse hemolytic plaque assay to study the regulation of anterior lobe acth acth secretion by acth releasing factor arginine vasopressin angiotensin ii and glucocorticoids. Endocrinology 120(2): 439-444, 1987

Circulating adrenocorticotropin (ACTH) as a controlled variable in the regulation of ACTH secretion. Canadian Journal of Physiology and Pharmacology 49(8): 744-751, 1971

Circulating acth as a controlled variable in the regulation of acth secretion. Canadian Journal of Physiology & Pharmacology 49(8): 744-751, 1971

Participation of central mono aminergic neurons in the regulation of anterior pituitary secretion. Martini, L And Joseph Meites (Ed ) Neurochemical Aspects Of Hypothalamic Function Symposium X+159p Illus Academic Press: New York, N Y , U S A ; London, England 61-83, 1970

Feedback regulation of acth secretion cortisol f infused over the physiological range results inc a concentration dependent decrease in plasma acth in the dog. Federation Proceedings 33(3 PART 1): 205, 1974

Regulation of ACTH levels in anterior pituitary cells during stimulated secretion: Evidence for aspartyl and cysteine proteases in the cellular metabolism of ACTH. Peptides (New York) 24(5): 717-725, 2003

Regulation of pituitary hormone secretion: regulation of ACTH secretion. Nihon Rinsho. Japanese Journal of Clinical Medicine 37(4): 755-761, 1979

Use of the reverse hemolytic plaque assay to study the regulation of anterior lobe adrenocorticotropin (ACTH) secretion by ACTH-releasing factor, arginine vasopressin, angiotensin II, and glucocorticoids. Endocrinology 120(2): 439-444, 1987

Hypothalamic mono aminergic neuro secretion and the regulation of pars intermedia activity in xenopus laevis tadpoles. Knowles, Francis And Lutz Vollrath (Ed ) Neurosecretion The Final Neuroendocrine Pathway Vi International Symposium London, England 1973 Ix+345p Illus Springer-Verlag: New York, N Y , U S A ; Berlin, West Germany Isbn 0-387-06821-X; Isbn 3-540-06821-X 323, 1974

Neurochemical fine tuning of a peripheral tissue: peptidergic and aminergic regulation of fluid secretion by Malpighian tubules in the tobacco hawkmoth M. sexta. Journal of Experimental Biology 205(Pt 13): 1869-1880, 2002

Regulation of ACTH secretion. Orvosi Hetilap 119(42): 2543-2552, 1978

The regulation of ACTH secretion by IL-1. Science 238(4826): 452-454, 1987