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The amino acid effect on growth of bacillus polymyxa 1538 and polymyxin b biosynthesis






Antibiotiki (Moscow) 24(11): 815-820

The amino acid effect on growth of bacillus polymyxa 1538 and polymyxin b biosynthesis

The effect of a number of the most important amino acids on the growth of B. polymyxa 1538 and polymyxin B biosynthesis was studied. All of the amino acids tested except DL-threonine and L-.alpha.-.gamma.-DABA [diamino butyric acid] inhibited the initial growth of the organism. DL-threonine and L-.alpha.-.gamma.-DABA had some stimulating effect on the culture growth without affecting the final accumulation of the biomass. The antibiotic synthesis proceeded more vigorously when the medium contained DL-threonine, L-.alpha.-.gamma.-DABA, L-asparagine, L-proline, L-glutamine, DL-asparaginic acid and L-glutamic acid in the concentrations tested. Neither of the tested amino acids used alone or in combination provided the levels of polymyxin B biosynthesis observed on the media contain ing rich sources of organic N.

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Accession: 006599144



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