The anabolic properties of the phyto ecdysone turkesterone and turkesterone tetra acetate in experiments on male rats
Syrov, V.N.; Kurmukov, A.G.
Problemy Endokria 22(3): 107-112
Turkesterone, a phytoecdysone isolated from Ajuga turkestanica, in a dose of 0.5 mg/100 g body wt accelerated body weight accretion by 1.7 times in sexually mature male rats, 2.6 times in sexually immature intact male rats, and 1.8 times in sexually immature castrated rats. Turkesterone tetraacetate in the same dose accelerated weight gain in these 3 groups by 2, 2.5 and 1.9 times, respectively. The stimulating effect of the 2 substances on organ (liver, heart, kidneys, musculus tibialis anterior, ventral prostate, seminal veiscles) weight and total protein level was more clearly expressed in young animals. The weight of the seminal vesicles and ventral prostate was essentially unchanges in infantile castrated rats and adult sexually mature rats, while it increased in the sexually immature intact animals. The differences between the anabolic effects of turkesterone and turkesterone tetraacetate and those of anabolic steroid drugs suggest a difference in their action mechanisms.