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The analgesic activity of calcitonin and the central serotonergic system

European Journal of Pharmacology 108(1): 71-76

The analgesic activity of calcitonin and the central serotonergic system

The effect of peripherally administered cyproheptadine or reserpine and the administration of 5,7-dihydroxytryptamine (5,7-DHT) in the nucleus raphe dorsalis on the analgesic activity of salmon calcitonin (sCT) injected into the lateral ventricle were investigated in male rats. Cyproheptadine or reserpine, given, respectively, 30 min or 24 h before the peptide, completely abolished the analgesic activity at all the times studied. When reserpine was given before the peptide it increased the effect of sCT at 30 (P < 0.01), 60 (P < 0.001), 120 (P < 0.01) and 180 (P < 0.01) min 5,7-DHT injected in the nucleus raphe dorsalis 15 days before the peptide led to complete abolition of the analgesic activity. If neurotoxin was injected 4 days before sCT, the effect of the peptide was significant (P < 0.05) only at 60 min. The analgesic activity of sCT may involve central serotonergic pathway(s) and the midbrain raphe nuclei 5-HT content is an important focus for this activity.

Accession: 006599787

PMID: 3979435

DOI: 10.1016/0014-2999(85)90284-5

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