+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The analysis of a titration study

The analysis of a titration study

Statistics in Medicine 6(5): 583-590

For analysis of data from a titration study, this paper adopts the idea of a life table analysis and utilizes a logistic linear dose-response model. The procedure use iterated reweighted least-squares to provide parameter estimates. Computation of the asymptotic covariance of the life-table estimates of the response rates involves Greenwood's formula and a conditioning argument. A special case consists of examination of the covariance structure when no dropouts took place. Data from a titration study that investigated the efficacy of an anti-hypertensive compound illustrate the procedure.

Accession: 006599854

Download citation: RISBibTeXText

PMID: 3659668

DOI: 10.1002/sim.4780060507

Download PDF Full Text: The analysis of a titration study

Related references

Applications of A. C. oscillopolarographic titration in pharmaceutical analysis. II. Titration of disodium dimercaptosuccinate with Cd. Yao Xue Xue Bao 17(8): 621-623, 1982

Applications of AC oscillopolarographic titration in pharmaceutical analysis. III. Titration of sulfathiazole with AgNO3. Yao Xue Xue Bao 17(10): 798-800, 1982

Polarometric titration in pharmaceutical analysis. VI. Possibility of determination of tartrates by titration with lead salts. Ceskoslovenska Farmacie 2(1): 14-15, 1953

Applications of A C oscillopolarographic titration in pharmaceutical analysis. I. Titration of neostigmine methyl sulfate injection with sodium tetraphenylborate. Yao Xue Xue Bao 17(7): 534-539, 1982

Affinity gel titration quantitative analysis of the binding equilibrium between immobilized protein and free ligand by a continuous titration procedure. Analytical Biochemistry 149(2): 369-378, 1985

Titration comparative study of TOPINA Tablets in patients with localization related epilepsy: double-blind comparative study by rapid and slow titration methods. Nihon Shinkei Seishin Yakurigaku Zasshi 32(2): 73-83, 2012

Titration of penicillin by the dilution method; experimental study of the factors influencing titration. Annales Pharmaceutiques Francaises 8(4): 300-316, 1950

Charge characteristics of humic and fulvic acids: comparative analysis by colloid titration and potentiometric titration with continuous pK-distribution function model. Chemosphere 73(4): 557-563, 2008

A model study on in vivo titration of genetic regulators lac repressor titration by episomal lac operator sites. Korean Journal of Biochemistry 17(2): 129-138, 1985

A study of the methods of measuring germicidal chlorine with reference to the oxidation reduction potential, starch-iodide titration and ortho-tolidine titration. Michigan Engineer Exp Sta Bull (91): 1-38, 1940

Analysis of adverse events in a dose titration study. Journal of Clinical Pharmacology 34(2): 136-141, 1994

Titration of cyanide and hexacyanoferrate(II) with silver nitrate-I Calculation of titration curves for potentiometric and conductometric titration. Talanta 25(3): 137-141, 1978

A study of the methods of measuring germicidal efficiency of chlorine with reference to the oxidation-reduction potential, starch-iodide titration and ortho-tolidine titration. Jour Amer Water Works Assoc 33(8): 1451-1452, 1941

A study of interferences in the EDTA titration of Ca and Mg in plant tissue analysis. Proc. Amer. Soc. hort. Sci, 80: 650-60. bibl. 18, 1962

Is automatic CPAP titration as effective as manual CPAP titration in OSAHS patients? A meta-analysis. Sleep & Breathing 16(2): 329-340, 2012