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The analysis of a titration study

Statistics in Medicine 6(5): 583-590

The analysis of a titration study

For analysis of data from a titration study, this paper adopts the idea of a life table analysis and utilizes a logistic linear dose-response model. The procedure use iterated reweighted least-squares to provide parameter estimates. Computation of the asymptotic covariance of the life-table estimates of the response rates involves Greenwood's formula and a conditioning argument. A special case consists of examination of the covariance structure when no dropouts took place. Data from a titration study that investigated the efficacy of an anti-hypertensive compound illustrate the procedure.

Accession: 006599854

PMID: 3659668

DOI: 10.1002/sim.4780060507

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