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The bucharest romania multi factorial prevention trial of coronary heart disease general methodology and risk factor correction after 5 year follow up 1971 1977


The bucharest romania multi factorial prevention trial of coronary heart disease general methodology and risk factor correction after 5 year follow up 1971 1977



Revue Roumaine de Medecine Medecine Interne 20(2): 117-136



Both the intervention and the control group included 5000 men aged 40-60 yr, randomly selected by their home address in 5 districts of the city of Bucharest. The intervention group underwent an at entry examination for risk factor detection (high serum cholesterol, high-blood pressure, overweight, diabetes, minor ECG abnormalities, family history) and subsequently a 5-yr multifactorial intervention aimed to reduce the risk factors. Both groups were followed up in this lapse of time for major end-points: myocardial infarction, stroke, sudden death. The qualitative analysis of the results used 10 evolution indices based on a quantal counting and led to a classification of risk factors which allowed the setting up of a strategy for their correction. The quantitative analysis showed the following decreases between the first and the last examination in the intervention group: for serum cholesterol .gtoreq. 250 mg/dl, 17%; for cigarettes/day .gtoreq. 15, 53%; for overweight .gtoreq. 30%, 13.57%; for high blood pressure, 8%; for the overall risk computed by multiple regression - 33.8%.

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