The bucharest romania multi factorial prevention trial the changes of morbidity and of general and specific mortality
Revue Roumaine de Medecine Medecine Interne 20(3): 197-208
The results of the Bucharest multifactorial prevention trial of coronary heart disease, concerning changes in cardiovascular morbidity and mortality during the first 5 yr period of follow-up, are presented. The age adjusted 5 yr rates disclose important reductions in the intervention groups in comparison with the control one: for hard events (myocardial infarction, stroke, acute coronary insufficiency), by 41%; for myocardial infarction, by 35%; for coronary mortality, by 38%; for stroke, by 39%; for cardiovascular mortality, by 30%. The decrease of hard events, myocardial infarction and stroke incidences is statistically significant. The evolution curves of cardiovascular morbidity an mortality show that both groups (the intervention and the control one) begin with near the same values, but on the way, and especially after 5 yr, they are differently located, those of the control group being higher than those of the intervention group.