EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

The central effects of trh on the breathing movements and electrocortical activity of the fetal sheep



The central effects of trh on the breathing movements and electrocortical activity of the fetal sheep



Pediatric Research 23(1): 72-75



The fetal respiratory and electrocortical effects of thyrotropin-releasing hormone (TRH) administered into the lateral cerebral ventricles, have been investigated in chronically catheterized unanesthetized fetal sheep at 125-140 days of gestation. Stimulatory effects on fetal breathing movements were seen at doses as low as a lug bolus. TRH given as a 5-.mu.g bolus followed by a 10 .mu.g/h infusion for 2 h induced a rapid switch to significantly faster, deeper, and continuous fetal breathing movements, while the electrocorticogram remained episodic. Fetal breathing movements did not stop during hypoxia. TRH given as a 2-.mu.g bolus followed by a 4 .mu.g/h infusion or as a 5-.mu.g bolus followed by a 5 .mu.g/h infusion induced the same stimulation of FBMs, but breathing essentially remained episodic, state related and inhibited by hypoxia. As hypothermia presumably induces a surge in TRH secretion at birth it is possible that TRH has some role in the switch from fetal to postnatal breathing patterns.

(PDF emailed within 1 workday: $29.90)

Accession: 006612267

Download citation: RISBibTeXText



Related references

The central effects of thyrotropin-releasing hormone on the breathing movements and electrocortical activity of the fetal sheep. Pediatric Research 23(1): 72-75, 1988

The effects of raising intracranial pressure on breathing movements, eye movements and electrocortical activity in fetal sheep. Journal of Developmental Physiology 8(2): 105-116, 1986

Effects of bilateral total pneumonectomy on breathing movements and electrocortical activity in fetal sheep. Pediatric Research 31(4 PART 2): 359A, 1992

Effects of increased core temperature on breathing movements and electrocortical activity in fetal sheep. Journal of Developmental Physiology 10(6): 513-523, 1988

Effects of moderate hypoxia on fetal electrocortical activity, eye movements, and breathing activity in sheep. Journal of Developmental Physiology 8(6): 411-419, 1986

Effect of morphine on fetal electrocortical activity and breathing movements in fetal sheep. Developmental Pharmacology and Therapeutics 8(2): 115-128, 1985

Effect of unilateral left pneumonectomy on fetal breathing movements and electrocortical activity in sheep. Pediatric Research 31(4 PART 2): 309A, 1992

The effect of carbonic anhydrase inhibition on breathing movements and electrocortical activity in fetal sheep. Respiration Physiology 61(3): 327-334, 1985

Electrocortical activity electroocular activity and breathing movements in fetal sheep with prolonged and graded hypoxemia. American Journal of Obstetrics & Gynecology 167(2): 553-558, 1992

Effects of glucose concentration on fetal breathing movements and electrocortical activity in fetal lambs. American Journal of Obstetrics and Gynecology 142(6 Pt 1): 678-683, 1982

Effects of clonidine on breathing movements and electrocortical activity in the fetal lamb. American Journal of Obstetrics & Gynecology 163(2): 661-668, 1990

Electrocortical activity, breathing and body movements, heart rate and blood pressure during mechanical pulmonary ventilation in fetal sheep. European Journal of Obstetrics & Gynecology and Reproductive Biology 19(5): 329-330, 1985

Effects of a prolonged infusion of a placental extract on breathing and electrocortical activity in the fetal sheep. Pediatric Research 41(4 PART 2): 300A, 1997

Effects of reduced uterine blood flow in electrocortical activity breathing and skeletal muscle activity in fetal sheep. American Journal of Obstetrics & Gynecology 154(3): 655-662, 1986

The central effects of morphine on fetal breathing movements in the fetal sheep. Journal of Developmental Physiology 8(4): 297-305, 1986