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The chemo therapy of rodent malaria part 24 the blood schizontocidal action of erythromycin upon plasmodium berghei



The chemo therapy of rodent malaria part 24 the blood schizontocidal action of erythromycin upon plasmodium berghei



Annals of Tropical Medicine and Parasitology 70(3): 253-258



Erythromycin inhibits chloroquine-induced pigment clumping in P. berghei in vitro. The drug was tested against infections of P. berghei in mice and was active at non-toxic doses. Given orally, the stearate salt was more effective than the base, but s.c., the base was more effective than the stearate. Erythromycin potentiated the action of chloroquine against 2 chloroquine-resistant strains of rodent malaria, the mildly resistant NS, and the highly resistant RC strains of P. berghei, but not against the drug-sensitive N strain.

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