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The chemo therapy of rodent malaria part 31 the effect of some metabolic inhibitors upon chloroquine induced pigment clumping in plasmodium berghei



The chemo therapy of rodent malaria part 31 the effect of some metabolic inhibitors upon chloroquine induced pigment clumping in plasmodium berghei



Annals of Tropical Medicine and Parasitology 72(3): 203-212



The effect of metabolic inhibitors upon CIPC in [mouse] intraerythrocytic P. berghei was studied in vitro. Oligomycin and venturicidin competitively inhibit the process with Ki values of 0.18 and 0.41 .mu.mol/l. DCCD [N,N'-dicyclohexylcarbodiimide], an agent thought to act upon a mitochondrial site close to that affected by oligomycin and venturicidin, causes pigment clumping in the absence of chloroquine (Km value 4.7 .mu.mol/l). After being concentrated in the cytoplasm by Fitch's high-affinity site, chloroquine may interact with a mitochondrial site; this interaction may initiate the pigment clumping process. Comparison of the effects of the ionophores 2,4,-dinitrophenol, monensin and valinomycin indicates that a pH gradient is involved at some stage in chloroquine-induced pigment clumping.

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Accession: 006614082

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Related references

The chemotherapy of rodent malaria, XXXI. The effect of some metabolic inhibitors upon chloroquine-induced pigment clumping (CIPC) in Plasmodium berghei. Annals of Tropical Medicine and Parasitology 72(3): 203-211, 1978

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