EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The chemotherapy of rodent malaria xxxix. ultrastructural changes following treatment with artemisinine of plasmodium berghei infection in mice with observations of the localization of tritiated dihydroartemisinine in plasmodium falciparum in vitro


Annals of Tropical Medicine and Parasitology 79(4): 367-374
The chemotherapy of rodent malaria xxxix. ultrastructural changes following treatment with artemisinine of plasmodium berghei infection in mice with observations of the localization of tritiated dihydroartemisinine in plasmodium falciparum in vitro
Ultrastructural changes were followed in Plasmodium berghei after the treatment of the mouse host with a single 10 mg kg-1 dose of artemisinine (qinghaosu). After 30 minutes, changes in the limiting and other membranes of the parasite were seen, together with alterations in ribosomal organization and endoplasmic reticulum. No changes were noted in digestive vacuoles or pigment, but nuclear membrane blebbing developed after one hour and segregation of the nucleoplasm after three hours. Further degenerative changes with disorganization and death occurred from eight hours onwards. The morphological changes in ribosomes and endoplasmic reticulum correlate in time with the depression in protein synthesis observed in P. falciparum in vitro. Similarly, the onset of nucleoplasmic segregation correlates with the development of nucleic acid synthesis inhibition. Tritiated reduced drug was shown to be localized in parasite membranes, indicating that changes in membrane integrity might precede the early depression of protein synthesis. Membrane association of artemisinine may be related to its amphipathic characteristics and similarity in some respects to a sterol.


Accession: 006614111



Related references

The chemotherapy of rodent malaria, XXXIX. Ultrastructural changes following treatment with artemisinine of Plasmodium berghei infection in mice, with observations of the localization of [3H]-dihydroartemisinine in P. falciparum in vitro. Annals of Tropical Medicine and Parasitology 79(4): 367-374, 1985

The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo. Journal of Infectious Diseases 176(5): 1327-1333, 1997

Studies on the sporogony of rodent malaria parasites plasmodium chabaudi plasmodium berghei berghei plasmodium berghei yoelii rats mice rabbit guinea pig. Annales des Societes Belges de Medecine Tropicale de Parasitologie et de Mycologie 48(1): 11-137, 1968

Chemotherapy of rodent malaria 35. further studies on the retardation of drug resistance by the use of a triple combination of mefloquine pyrimethamine and sulfadoxine in mice infected with plasmodium berghei n and plasmodium berghei ns. Annals of Tropical Medicine and Parasitology 78(5): 459-466, 1984

The chemotherapy of rodent malaria 38. studies on the activity of 3 new antimalarials wr 194965 4 tert butyl 2 tert butylaminomethyl 6 4 chlorophenylphenol wr 228258 terbuquine and wr 225448 8 4 amino 1 methylbutylamino 6 methoxy 4 methyl 5 3 trifluoroamethylphenoxyquinoline against rodent and human malaria parasites plasmodium berghei and plasmodium falciparum. Annals of Tropical Medicine and Parasitology 78(6): 567-580, 1984

The chemotherapy of rodent malaria, XXXVIII. Studies on the activity of three new antimalarials (WR 194,965, WR 228,258 and WR 225,448) against rodent and human malaria parasites (Plasmodium berghei and P. falciparum). Annals of Tropical Medicine and Parasitology 78(6): 567-579, 1984

Active immunization against the malaria parasite plasmodium berghei in mice sulfathiazole treatment of a plasmodium berghei infection and development of immunity. Tropenmedizin und Parasitologie 28(2): 158-174, 1977

Immuno suppression in malaria infection depression of antibody response in vitro in mice infected with rodent malaria plasmodium berghei. Japanese Journal of Parasitology 29(6): 463-472, 1980

Studies of splenomegaly in rodent malaria. II. The course of splenomegaly, IgM, IgG levels and IgG immunofluorescent antibody titre in mice after infection with Plasmodium berghei yoelii and-or Plasmodium chabaudi. Transactions of the Royal Society of Tropical Medicine and Hygiene 65(4): 490-500, 1971

Standardization of chemotherapy of rodent malaria (Plasmodium berghei) on NMRI mice. Zeitschrift für Tropenmedizin und Parasitologie 16(3): 258-268, 1965