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The choice of medium suitable for the reaction of thiol groups with halogen derivatives in the synthesis of some purine and pyrimidine compounds part 1 synthesis of azathioprine


Polish Journal of Pharmacology and Pharmacy 30(4): 593-599
The choice of medium suitable for the reaction of thiol groups with halogen derivatives in the synthesis of some purine and pyrimidine compounds part 1 synthesis of azathioprine
Investigations were carried out using 6-mercaptopurine and 1-methyl-4-nitro-5-chloroimidazole as model compounds. The reaction kinetics were investigated by the UV spectroscopy at various time intervals. An efficient synthesis of azathioprine [an immunosuppressive drug] which can be applied on an industrial scale in a yield of 80% was elaborated.


Accession: 006614432



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