+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The chromosome complement of a measles carrier human cell line in comparison to the cell line of origin

The chromosome complement of a measles carrier human cell line in comparison to the cell line of origin

Hereditas (Lund) 83(1): 91-104

G- and C-banding techniques were used for a karyotype analysis of measles-carrier human cells and the cell line of origin, Lu106, which is most likely a HeLa-derivative. The carrier cells showed a wider distribution of chromosome numbers and a lower stemline number (64-66) than in Lu106 (70). The percentage of marker chromosomes was slightly but significantly higher in carrier cells (40.7%) than in Lu106 (35.7%). A certain proportion (41.8%) of the carrier markers were new types, the origin of which might be attributed to structural rearrangements in Lu106 normal or marker chromosomes. They could also represent Lu106 markers not recorded in the sample analyzed of these cells. Certain new marker types were possible to identify as modified Lu106 marker types; others were similar to certain HeLa marker types. The total relative length of the chromosomal complement in the carrier cells was slightly lower than in Lu106. These values were also more variable in the carrier cells. This was largely due to variations in the total lengths of the new marker types. Large markers were common, possibly indicating a frequent involvement of large chromosomes in rearrangements. Markers are apparently more prone to undergo further structural changes. The lower uniformity and stability of the carrier cells is most likely a consequence of their persistent infection with measles virus.

(PDF 0-2 workdays service: $29.90)

Accession: 006614682

Download citation: RISBibTeXText

PMID: 965244

Related references

The chromosome complement of a measles-carrier human cell line in comparison to the cell line of origin. Hereditas 83(1): 91-104, 1976

Ultrastructure of a measles-carrier human cell line. Acta Pathologica et Microbiologica Scandinavica. Section A, Pathology 81(3): 281-290, 1973

Electron microscopy of mitotic cells in a measles carrier human cell line. Hereditas (Lund) 83(2): 257-263, 1976

Effect of direct cell to cell interaction between the km 102 clonal human marrow stromal cell line and the hl 60 myeloid leukemia cell line on the differentiation and proliferation of the hl 60 line. Cancer Research 47(11): 2879-2882, 1987

Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line. Journal of the National Cancer Institute 93(11): 865-872, 2001

Persistent measles virus infection in a calf kidney cell line. Note II. Study of some biological markers of the measles virus isolated from a selected chronically infected cell line. Virologie 29(2): 141-147, 1978

Measles virus from a long-term persistently infected human T lymphoblastoid cell line, in contrast to the cytocidal parental virus, establishes an immediate persistence in the original cell line. Journal of General Virology 73: 2195-2202, 1992

Studies on syncytia formation in a cell line (LU 106) of human origin after treatment with measles virus. Hereditas 57(3): 369-372, 1967

A carrier cell line of measles virus in Lu 106 cells. Archiv für die Gesamte Virusforschung 20(2): 215-224, 1967

Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity. Canadian Journal of Physiology and Pharmacology 88(4): 448-455, 2010

Comparison of an EBV transformed cell line and an EBV hybridoma cell line producing the same human anti-HBs monoclonal antibody. Journal of Virological Methods 37(1): 1-11, 1992

Comparison of drug sensitivity of parent human colon cancer cell line with resistant cell line. FASEB Journal 9(3): A95, 1995

Comparison of gene mutation at thymidine kinase (tk) locus between mouse lymphoma cell line L5178Y and human lymphoblastoid cell line TK6. Mutation Research/Environmental Mutagenesis and Related Subjects 359(3): 204-205, 1996

Persistent measles virus infection in a calf kidney cell line 4. electron microscopic observations in the k 2 cell line. Revue Roumaine de Medecine Virologie 31(2): 125-130, 1980

Persistent measles virus infection in a calf kidney cell line. Note IV. Electron microscopic observations in the K-2 cell line. Virologie 31(2): 125-129, 1980