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The chronic effect of coenzyme q10 for dilated cardiomyopathy echocardiographic assessment

Respiration & Circulation 36(6): 655-660

The chronic effect of coenzyme q10 for dilated cardiomyopathy echocardiographic assessment

To evaluate the chronic effect of coenzyme Q10 (CoQ10) to dilated cardiomyopathy (DCM), sixteen patients with DCM were studied by echocardiography. Seven of sixteen patients were received CoQ10 45 mg per day for five months (CoQ10 group). Nine of them were followed without CoQ10 for five months (non-CoQ10 group). Blood pressure and heart rate were not significantly changed in both groups. In echocardiographic findings, left ventricular end-diastolic dimension (Dd) was not significantly changed, end-systolic dimension (Ds) was increased from 52 .+-. 5 mm to 55 .+-. 6 mm and percent fractional shortening (%FS) decreased from 22 .+-. 5% to 18 .+-. 6% (p < 0.05) in non-CoQ10 group. In CoQ10 group, Dd and Ds tended to increase slightly (n.s.) and %FS tended to increase (21 .+-. 5% to 23 .+-. 5%, n.s.). Although symptom of heart failure was deteriorated in three of nine patients in non-CoQ10 group, it was aggravated in one and was improved in two of seven patients in CoQ10 group. That is to say, although in non-CoQ10 group cardiac contractility decreased progressively for five months, it was not significantly changed in CoQ10 group. These results suggested that CoQ10 might prevent the progression of myocardial lesion in DCM.

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Accession: 006614850

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