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The chronotropic action of glucagon in the dog under different experimental conditions


Journal de Pharmacologie (Paris) 7(1): 5-16
The chronotropic action of glucagon in the dog under different experimental conditions
Glucagon increased ventricular automatism of dogs in atrio ventricular heart block (AV block). This increase is not significant in anesthetized animals (chloralose 8 cg/kg) in acute AV block but is very significant in both conscious and anesthetized animals in chronic AV block. Values for the ventricular rate under glucagon are similar, irrespective of experimental conditions. The atrial rate varies considerably, depending on experimental conditions. It increases to 250 systoles/min approximately, in anesthetized dogs subjected to surgical trauma. It increases to 130-150 systoles/min in conscious animals in chronic AV block, and falls, even during perfusion. These differences are also found in animals when the atrio ventricular conduction pathways are left intact. A comparative study of the levels seen in different series, at 5 min after administration, rules out the influence of AV block itself. It accentuates the influence of anesthesia or surgical shock because of the changes of extrinsic innervation that these induce. Variations in vagal activity may play a more important role than that of the orthosympathetic innervation.

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Accession: 006614915



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