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The clinical value of free drug level monitoring in patients on monotherapy with carbamazepine phenytoin or sodium valproate



The clinical value of free drug level monitoring in patients on monotherapy with carbamazepine phenytoin or sodium valproate



Acta Therapeutica 12(4): 337-352



Free drug levels were monitored in patients on monotherapy with carbamazepine (n = 33), phenytoin (n = 24) and sodium valproate (n = 24) for a period of 12 months. We found no clinical value from monitoring free levels of carbamazepine. Free drug levels of phenytoin proved a better index of acute toxicity than total levels but only in three patients. Monitoring free drug levels of sodium valproate showed that patients with partial seizures required higher levels for seizure control than did patients with generalized seizures.

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