+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The complement c 4 and slp genes of the complement region of the murine h 2 major histocompatibility complex



The complement c 4 and slp genes of the complement region of the murine h 2 major histocompatibility complex



Philosophical Transactions of the Royal Society of London B Biological Sciences 306(1129): 395-404



Recent analyses, at the protein and DNA levels of structure, of the murine complement component C4 and the closely related sex-limited protein, Slp, have led to new insights into the H-2/S region-linked C4 and Slp genes and their products. The primary products are 200,000 dalton precursors which are cleaved, intracellularly and extracellularly, into the mature .alpha.-.beta.-.gamma.-subunit molecules of plasma. Precursor order of subunits is .beta.-.alpha.-.beta.; a complementary DNA clone spanning the .alpha.-.gamma. junction was extensively analyzed. The C-terminal of the .alpha.-chain is of particular interest because of post-secretion processing which differentiates secreted and plasma forms of C4, both apparently functional, and because allelic variants of C4 and the Slp protein, which differ substantially in molecular masses, owe their differences principally to different levels of glycosylation of the .alpha.-chain. Allelic variations in rate of C4 synthesis (C4-high compared with C4-low) were analyzed in cultures of hepatocytes and macrophages. Three distinct modes of genetic regulation of the expression of the Slp protein were identified.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006617658

Download citation: RISBibTeXText


Related references

The C4 and Slp genes of the complement region of the murine H-2 major histocompatibility complex. Philosophical Transactions of the Royal Society of London, B Biological Sciences 306(1129): 395-403, 1984

Biochemistry and Genetics of Compliment || The C4 and Slp Genes of the Complement Region of the Murine H-2 Major Histocompatibility Complex. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 306(1129): 395-403, 1984

Genetic susceptibility to murine collagen ii autoimmune arthritis proposed relationship to the immunoglobulin g 2 autoantibody subclass response complement c 5 major histocompatibility complex and non major histocompatibility complex. Journal of Experimental Medicine 162(6): 1878-1891, 1985

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B. Nature 307(5948): 237-241, 1984

A dna restriction fragment length polymorphism in the complement region of the human major histocompatibility complex shows an absolute correlation with polymorphism of complement factor b bf defined by isoelectric focusing. Journal of Immunogenetics 12(6): 321-326, 1986

Human complement genes of the major histocompatibility complex. Peeters, H (Ed ) Protides Of The Biological Fluids, Vol 33 33rd Colloquium, Brussels, Belgium, Xxiii+697p Pergamon Press: Oxford, England; New York, N Y , Usa Illus 43-46, 1985

Major histocompatibility complex complement genes and disease. Immunogenetic approaches to the control of endoparasites with particular reference to parasites of sheep Proceedings of a workshop held at Sydney University, October 22-23-1983, on behalf of the Australian Wool Corporation: 112-125, 1984

Evidence for mapping pig complement c 4 genes within the pig major histocompatibility complex. Animal Blood Groups and Biochemical Genetics 16(1): 65-68, 1985

Genetic mapping of C4 and Bf complement genes in the rat major histocompatibility complex. Immunogenetics 28(1): 57-80, 1988

Mapping of steroid 21-hydroxylase genes adjacent to complement component C4 genes in HLA, the major histocompatibility complex in man. Proceedings of the National Academy of Sciences of the United States of America 82(2): 521-525, 1985

Haplotype study on complement c 4 polymorphism in japanese associations with major histocompatibility complex alleles complotypes and hla complement haplotypes. Immunogenetics 22(4): 359-366, 1985

Thyrogastric autoimmunity and major histocompatibility complement associated alleles at the major histocompatibility complement c 4 locus in patients with type 1 insulin dependent diabetes. Diabetologia 27(Suppl.): 124-125, 1984

Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci. Nucleic Acids Research 18(24): 7251-7257, 1990

Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. Proceedings of the National Academy of Sciences of the United States of America 86(22): 8955-8958, 1989

Regulation of expression of the complement component genes encoded in the major histocompatibility complex. Complement 4(3-4): 240-241, 1987