The cyto genetic effect of steroid hormones in the culture of human peripheral blood lymphocytes

Toidze, N.Sh

Soobshcheniya Akademii Nauk Gruzinskoi SSR 109(3): 613-616

1983


Accession: 006623247

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Abstract
The cytogenetic effect of steroid hormones (dexamethasone, hydrocortisone and prednisolone) in the culture of human peripheral blood lymphocytes in increasing concentrations (10-7-10-4 M) was studied. Dexamethasone and prednisolone in concentrations of 10-6-10-5 M cause an increase of the total number of abnormal cells, mainly at the expense of polyploid cells. A maximal level of polyploidy is induced by prednisolone in concentration 10-6 M, reaching 5.4 .+-. 0.6% (polyploid cells are absent in the control).