+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The diagnosis of aspirin idiosyncrasy by analgesic challenge

Clinical Allergy 6(2): 177-181

The diagnosis of aspirin idiosyncrasy by analgesic challenge

Analgesic challenge was employed to identify fifty patients with aspirin idiosyncrasy. No serious reactions were observed using the method described. Patients with a history of the condition were highly sensitive and reacted to small doses of aspirin or to paracetamol. Patients with a positive challenge test, but previously unaware of aspirin idiosyncrasy, were less sensitive; they required larger challenge doses of aspirin and did not respond to paracetamol challenge. In the absence of an in vitro test, analgesic challenge is the only means of confirming the presence of aspirin idiosyncrasy.

Accession: 006628304

PMID: 1277441

DOI: 10.1111/j.1365-2222.1976.tb01896.x

Download PDF Full Text: The diagnosis of aspirin idiosyncrasy by analgesic challenge

Related references

Comparative studies on inhalation challenge tests by aspirin sulpyrin and tolmetin for diagnosis of analgesic induced asthma. Japanese Journal of Medicine 21(4): 317, 1982

Nares as a possible early stage of aspirin idiosyncrasy Necessity of a right diagnosis of rhinitis. Allergy (Copenhagen) 51(SUPPL 31): 104, 1996

Prolonged bleeding times after aspirin ingestion in patients with aspirin idiosyncrasy. Annals of Allergy 37(3): 191-194, 1976

Aspirin idiosyncrasy in systemic mast cell disease: A new look at mediator release during aspirin desensitization. Mayo Clinic Proceedings 70(5): 481-487, 1995

Clinical responses and serum prostaglandin levels in aspirin idiosyncrasy effect of aspirin and a new nonsteroidal anti inflammatory agent. Chest 80(6): 676-681, 1981

Pulmonary prostaglandin and clinical response of asthmatic patients with aspirin idiosyncrasy to a new nonsteroid anti inflammatory substance compared to aspirin. Journal Of Allergy & Clinical Immunology: 154-155, 1979

Nasal Lysine Aspirin Challenge In The Diagnosis Of Aspirin Exacerbated Respiratory Disease. Clinical & Experimental Allergy 43(8): 874-880, 2013

Acoustic rhinometry in the diagnosis of aspirin-induced asthma by lysine-aspirin challenge. European Respiratory Journal Supplement 10(25): 476S, Sept, 1997

Improvements in an oral aspirin challenge protocol for the diagnosis of aspirin hypersensitivity. Clinical and Experimental Allergy 35(6): 717-722, 2005

First complete description of the aspirin idiosyncrasy-asthma-nasal polyposis syndrome (plus urticaria)--1922 (with a note on aspirin desensitization). By F. Widal, P. Abrami, J. Lermoyez. Journal of Asthma 24(5): 297-300, 1987