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The diagnosis of stuart prower disease

, : The diagnosis of stuart prower disease. Problemy Gematologii i Perelivaniya Krovi 22(3): 46-49

Two brothers showed clinical symptoms indicating either coagulation disorders or hemophilia, including late bleeding after tooth extraction and surgery. These hemorrhages were successfully treated with preserved plasma transfusions, suggesting a factor .times. deficiency. Frequent nosebleeds also seemed to indicate such a diagnosis. Coagulographic analyses confirmed this suspicion. An analogous but unmanifested disorder was present in the boys' father, while the mother and other relatives showed no such disturbance. Analysis of the condition of blood coagulation as a whole and of its phases is sufficient for the diagnosis of isolated coagulation defects, and special tests of the activity of each factor are unnecessary.

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