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The diagnostic and therapeutical problems of latent toxoplasmosis in pregnancy

, : The diagnostic and therapeutical problems of latent toxoplasmosis in pregnancy. Wiadomosci Parazytologiczne 30(3): 321-330

In the 1st Obstetric Clinic at the Medical Academy in Wroclaw [Czechoslovakia] 614 pregnant women, who have been hospitalized with various clinical diagnoses during 8 yr (1974-1981), had a positive serologic test which indicated toxoplasmosis. Although in 75% of cases no therapy was undertaken, toxoplasmosis was not diagnosed in either mothers or infants. As the currently serologic tests are often unreliable an attempt should be made to establish more precise laboratory critera qualifying for treatment of toxoplasmosis in pregnancy. Although the opinions on the efficacy of asymptomatic toxoplasmosis therapy in pregnancy are divided, no complications (in mother or in fetus) result from such treatment, while nontreatment may have its moral and legal consequences. Antitoxoplasma therapy seems necessary for every woman with positive serologic result and obsterical anamnesis, especially in those cases where the change of titer from negative to positive or an ascending titer have been observed.

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Related references

Podgórnik, F., 1977: Latent toxoplasmosis as a possible cause of pregnancy losses, including developmental malformations: diagnostic tests, treatment and follow-up observations. Ginekologia Polska 48(9): 783-788

Robaczyński, J.; Wilczyński, A.; Kaniak, M.; Michalik, T., 1984: Diagnostic and therapeutic problems of chronic toxoplasmosis in pregnancy. Wiadomosci Parazytologiczne 30(3): 321-330

Vivell, O.; Buhn, W.H., 1953: Problem of toxoplasmosis in pregnancy; results of serological studies in fertile women as well as evaluation of aureomycin prophylaxis of the latent toxoplasmosis. Arztliche Forschung 7(7): I/326-I/335

Piolino M., 1971: Therapeutical problems of acquired toxoplasmosis. Hentsch, Didier (Ed ) Toxoplasmosis 264p Illus Hans Huber Publishers: Bern, Switzerland 244-250

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Decio, R., 1961: Latent toxoplasmosis in pregnancy. Rivista di Ostetricia E Ginecologia 16: 221-223

Biedermann, K.; Flepp, M.; Fierz, W.; Joller-Jemelka, H.; Kleihues, P., 1995: Pregnancy, immunosuppression and reactivation of latent toxoplasmosis. Toxoplasmosis is a chronic, latent infection which can be reactivated in the presence of immunosuppression. The critical question in obstetrics is whether toxoplasmosis may be reactivated in the presence of the physiological "immunosuppressio...

Sauer, J.; Simek, J., 1961: Effect of latent maternal toxoplasmosis on the course and fate of pregnancy. Ceskoslovenska Gynekologie 26: 500-505