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The effect of a long term carbon tetra chloride action on the dna content of rat liver cell nuclei a cyto photometric study



The effect of a long term carbon tetra chloride action on the dna content of rat liver cell nuclei a cyto photometric study



Folia Histochemica et Cytochemica 13(3-4): 207-212



Inbred CFY male and female rats were given s.c. injections of CCl4 solution in sunflower oil for 12 wk. Cytophotometric DNA determinations were made on liver cell nuclei. Cell nuclei from normal liver showed modal peak of DNA in the diploid range. In the treated animals there were modal peaks of DNA in diploid and tetraploid regions and remarkable numbers of over-tetraploid nuclei. The hepatic lesions classified histologically were more severe in males than in females. The ploidy distributions were not related to the histopathological features or sex.

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