Section 7
Chapter 6,638

The effect of atrial natriuretic peptide on plasma renin activity, plasma aldosterone, and urinary dopamine in man

Struthers, A.D.; Anderson, J.V.; Payne, N.; Causon, R.C.; Slater, J.D.; Bloom, S.R.

European Journal of Clinical Pharmacology 31(2): 223-226


ISSN/ISBN: 0031-6970
PMID: 2948826
DOI: 10.1007/bf00606663
Accession: 006637938

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The acute natriuretic effect of human atrial natriuretic peptide (ANP) has been well described in man. We have now studied possible hormonal mediators of this effect. We studied six healthy volunteers on two occasions when they received either an infusion of ANP of 1.5 pmol .cntdot. kg-1 .cntdot. min-1 for 30 min followed by 15 pmol .cntdot. kg-1 .cntdot. min-1 for a further 30 min, or matching vehicle infusions in a randomized single-blind fashion. On the placebo day, plasma renin activity (PRA) rose from 1.26 .+-. 0.08 to 1.57 .+-. 0.14 ng A1 .cntdot. ml-1 .cntdot. h-1, while on the ANP study day PRA fell from 1.45 .+-. 0.15 to 1.28 .+-. 0.05 ng A1 .cntdot. ml-1 .cntdot. h-1 (p < 0.01). No significant changes were found in plasma aldosterone concentrations or in urinary dopamine excretion. These results provide evidence that ANP suppresses renin release in man.

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