Section 7
Chapter 6,642

The effect of di butyryl cyclic gmp a competitive antagonist to cholecystokinin pancreozymin on gastric acid secretion in the isolated mouse stomach

Davison, J.S.; Najafi Farashah, A.

Life Sciences 31(4): 355-362


ISSN/ISBN: 0024-3205
Accession: 006641526

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Dibutyryl cGMP (dbcGMP), a specific competitive inhibitor of the gastrin, cholecystokinin-pancreozymin (CCK-PZ) family of peptides in pancreas, gallbladder and ileum, had no effect on basal acid secretion in the isolated mouse stomach nor on secretion stimulated by bethanechol or histamine. Secretion evoked by low doses of pentagastrin were likewise unaffected by dbcGMP, but responses to high doses of pentagastrin were augmented. CCK-PZ and glucagon each inhibited acid secretion evoked by pentagastrin. DbcGMP blocked CCK-PZ mediated inhibition, but was without effect on inhibition by glucagon. In the pancreatic glands there may exist 2 receptors with different affinities for gastrin and CCK-PZ which mediate excitation and inhibition, respectively.

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