Section 7
Chapter 6,642

The effect of dichloromethane on the oxygenation of hemoglobin

Saxena, A.M.; North, B.E.; Schoenborn, B.P.

Biochimica et Biophysica Acta 704(1): 1-6


ISSN/ISBN: 0006-3002
PMID: 7093282
Accession: 006641529

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Dichloromethane is an anesthetic that weakly binds to human Hb at 4 different sites. It also reduces the gelation of Hg S. Hb oxygenation curves were measured for different partial pressures of dichloromethane. These curves show that the O2 binding to Hb remains cooperative in the presence of dichloromethane. Application of the thermodynamic approach suggests that only one of the binding sites is responsible for decreasing Hb O2-affinity.

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