The effect of ethanol on early development in mice and rats 1. in vivo effect on pre implantation and early post implantation stages
Sandor, S.; Checiu, M.; Fazakas-Todea, I.; Garban, Z.
Revue Roumaine de Morphologie d'Embryologie et de Physiologie Morphologie et Embryologie 26(3): 265-274
The preimplantation and early postimplantation effect of chronic alcohol consumption (at least 1 mo. before mating and during pregnancy until killing) and of acute ethanol intoxication during the preimplantation period (i.v. injection of ethanol) was studied on albino rats (Wistar) and albino mice (RAP). Chronic alcoholization in rats caused significant retardation of preimplantation development and of early postimplantation stages; there was a tendency of lowering of the mean litter size. In mice there was significant increase of the number of preimplantation pathological forms and a tendency of lowering of the mean litter size. Pathological changes show, in rats and mice, an obvious litter effect. Acute ethanol intoxication in rats caused significant retardation in some litters, normal or even advanced development in others. This effect differs from the previously reported effect of acute ethanol intoxication during early postimplantation stages. There is a prenatal noxious effect of chronic ethanol consumption in both species and of acute ethanol intoxication during preimplantation development upon early postimplantation develop in rats. Within the limits of extrapolation possibilities, they represent a risk signal for other species (including human).