+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The effect of goat milk fractions on synthesis of milk constituents by rabbit mammary explants and on milk yield in vivo. Evidence for autocrine control of milk secretion



The effect of goat milk fractions on synthesis of milk constituents by rabbit mammary explants and on milk yield in vivo. Evidence for autocrine control of milk secretion



Biochemical Journal 242(1): 285-288



1. Lactose and casein synthesis by rabbit mammary explants in organ culture was inhibited when fractions of goat milk were included in the culture medium. Inhibition was dose-dependent, and readily reversed when milk fractions were removed. 2. The pattern of effects obtained with various fractions of milk indicated that inhiibition was caused by a protein of 10,000-30,000 Da, which was present in the milk serum or whey fraction. 3. The inhibitor fraction decreased milk accumulation when injected into lactating rabbit mammary glands via the teat ducts, whereas other milk proteins had no effect. 4. Results are discussed in terms of autocrine regulation of milk synthesis through negative feedback by milk constituents.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 006644738

Download citation: RISBibTeXText

PMID: 3593242

DOI: 10.1042/bj2420285


Related references

Inhibition of lactose and casein synthesis in rabbit mammary explants by fractions of goat milk. Biochemical Society Transactions 13(2): 385-386, 1985

Role of the efferent innervation of the goat mammary gland in the regulation of milk secretion. I. Effect of denervation of the mammary gland on secretion of milk, milk fat, casein and lactose at different stages of the lactation in which the operation was performed. Neiro-gormonal' naya regulyatsiya laktatsii. Moscow: IzdateFstvo "Nauka", 62-78, 1966

Feed-back inhibition of milk secretion: the effect of a fraction of goat milk on milk yield and composition. Quarterly Journal of Experimental Physiology 73(3): 391-397, 1988

Effects of removing milk from the mammary ducts and alveoli, or of diluting stored milk, on the rate of milk secretion in the goat. Quarterly Journal of Experimental Physiology 72(1): 13-19, 1987

Phenotypic correlations among milk yield, milk fat yield and milk protein yield, and the percentages of milk constituents in milk of primiparous cows. Acta Academiae Agriculturae ac Technicae Olstenensis, Zootechnika (299 (Zootechnika 30)): 117-124, 1987

Distribution of milk in the goat mammary gland and its relation to the rate and control of milk secretion. Journal of Dairy Research 55(1): 41-48, 1988

Effect of milk and milk protein fractions on the amino acid incorporation by the mammary gland and liver tissue from goat in vitro. Milchwissenschaft 32(3): 146-150, 1977

Effect of environmental factors on milk and butterfat ejection and on the contents of some milk constituents in various fractions of milk obtained at a single milking.. Dokl. vsesoyuz. Konf. moloch. Delu. 42-48, 1958

Effect of Chronic Stimulation of the Afferent Nerves of the Mammary Gland in the Goat on the Secretion of Milk and Milk Fat. Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 49: 1188-1196, 1963

Effect of a fraction of goat milk serum proteins on milk accumulation and enzyme activities in rabbit mammary gland. Biochemical Society Transactions 15(5): 916-917, 1987

Effect of stage of lactation on milk yield and major milk constituents of Muzzafarnagri ewes' milk. Indian Veterinary Journal 76(10): 944-945, 1999

Studies on ewe's milk. 5. The effect of high cereal diets on ewes and on the yield of milk and milk constituents. Journal of Agricultural Science. 78: 2, 203-213, 1972

Biochemical changes in buffalo milk Cheddar cheese as affected by the incorporation of goat milk and goat milk fat fractions. Indian Journal of Dairy Science 53(1): 19-25, 2000

The effect of selenium and iodine supplementation during pregnancy and lactation on milk yield, milk fat and milk protein secretion in Karakachan ewes. Zhivotnov"dni Nauki ( Suppl. 2): 49-52, 1998

Evidence that growth hormone stimulates milk synthesis by direct action on the mammary gland and that prolactin exerts effects on milk secretion by maintenance of mammary deoxyribonucleic acid content and tight junction status. Endocrinology 135(3): 1119-1124, 1994