The effect of propranolol on portal hypertension in patients with cirrhosis: a hemodynamic study

Lebrec, D.; Hillon, P.; Muńoz, C.; Goldfarb, G.; Nouel, O.; Benhamou, J.P.

Hepatology 2(5): 523-527

1982


ISSN/ISBN: 0270-9139
PMID: 6981575
DOI: 10.1002/hep.1840020502
Accession: 006652505

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Abstract
The gradient between wedged and free hepatic venous pressures was measured in patients with alcoholic cirrhosis before and 1, 3 and 9 mo. after continuous oral administration of propranolol at doses reducing the heart rate by 25% or after administration of a placebo. The gradient between wedged and free hepatic venous pressures decreased throughout the duration of propranolol administration, and it did not significantly change in the patients receiving placebo. Since the gradient between wedged and free hepatic venous pressures closely reflects portal venous pressure in alcoholic cirrhosis, continuous oral administration of propranolol apparently produced sustained reduction in portal venous pressure in these patients.

The effect of propranolol on portal hypertension in patients with cirrhosis: a hemodynamic study