The effect of propranolol on postischemic acute renal failure in the rat

Solez, K.; Freshwater, M.F.; Su, C.T.

Transplantation 24(2): 148-151

1977


ISSN/ISBN: 0041-1337
PMID: 331571
DOI: 10.1097/00007890-197708000-00009
Accession: 006652506

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Abstract
Whether propranolol might be a useful agent to prevent postischemic acute renal failure in the transplanted kidney and whether a single i.v. bolus injection of propranolol would have the same effect as an i.v. infusion was assessed. Propranolol apparently had a beneficial effect in postischemic acute renal failure. The drug was ineffective in the transplanted (and therefore denervated) kidney damaged by ischemia, presumably because propranolol's main effect is to inhibit neurogenically stimulated renin release. Denervation was associated with more severe renal functional failure, but it is unclear whether this is a direct effect of denervation, perhaps mediated through elimination of .alpha.-adrenergic inhibition of renin release or a nonspecific effect on renal artery trauma. Propranolol might be beneficial when given as a pretreatment prior to harvesting of a kidney for transplantation. Morphological changes that occur in the rat following renal ischemia are unlike those seen in man and in the rabbit. This is one reason why the rat may be undesirable as a transplantation model.