Section 7
Chapter 6,653

The effect of prostaglandin e 2 cyclic amp and histamine on the synthesis of glyco proteins in isolated cells of rat gastric mucosa

Tairov, M.M.; Bersimbaev, R.I.; Salganik, R.I.

Biokhimiya 49(1): 25-31


Accession: 006652587

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Prostaglandin E2 (PGE2), but not histamine, increased the incorporation of 3H-N-acetyl-D-glucosamine and 14C-amino acids into the acid-insoluble protein fraction of isolated, mainly mucous cells of the rat gastric mucosa. cAMP at a dose of 1 mM enhanced, like PGE2, the synthesis of gastric mucus. Cycloheximide inhibited the basal incorporation of labeled N-acetyl-D-glucosamine and the amino acid mixture by 28 and 72%, respectively, and completely blocked the PGE2 effect on glycoprotein formation. PGE2, unlike histamine, apparently enhances the biosynthesis of glycoproteins in the mucous cells of the rat gastric mucosa. cAMP is believed to be a messenger of the PGE2 effect.

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