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The effect of the cholin esterase inhibitor armin on the nerve muscle synapse of the frog sartorius muscle


Fiziologicheskii Zhurnal SSSR Imeni I M Sechenova 62(9): 1310-1316
The effect of the cholin esterase inhibitor armin on the nerve muscle synapse of the frog sartorius muscle
The organophosphorus cholinesterase inhibitor armin (2 .cntdot. 10-9.sbd.2 .cntdot. 10-4 M) prolonged postjunction potentials and in concentration 2 .cntdot. 10-9.sbd.2 .cntdot. 10-7 M increased the amplitude of miniature end-plate potentials (mepps) irreversibly. Armin (2 .cntdot. 10-6.sbd.2 .cntdot. 10-4 M) decreased the frequency of mepps and quantum content of epps. These parameters were increased again after washing. Thus, armin (2 .cntdot. 10-9.sbd.2 .cntdot. 10-7 M) exerts anticholinesterase effect only. In concentrations 2 .cntdot. 10-6.sbd.2 .cntdot. 10-4 M, in addition to the anticholinesterase effect, it affects presynaptic membrane and inhibits postsynaptic membrane cholinoreceptors.

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Accession: 006656657



Related references

Effect of the cholinesterase inhibitor armin on meuromuscular synapse function of the frog sartorius muscle. Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 62(9): 1310-1316, 1976

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