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The effect of the cholin esterase inhibitor armin on the nerve muscle synapse of the frog sartorius muscle



The effect of the cholin esterase inhibitor armin on the nerve muscle synapse of the frog sartorius muscle



Fiziologicheskii Zhurnal SSSR Imeni I M Sechenova 62(9): 1310-1316



The organophosphorus cholinesterase inhibitor armin (2 .cntdot. 10-9.sbd.2 .cntdot. 10-4 M) prolonged postjunction potentials and in concentration 2 .cntdot. 10-9.sbd.2 .cntdot. 10-7 M increased the amplitude of miniature end-plate potentials (mepps) irreversibly. Armin (2 .cntdot. 10-6.sbd.2 .cntdot. 10-4 M) decreased the frequency of mepps and quantum content of epps. These parameters were increased again after washing. Thus, armin (2 .cntdot. 10-9.sbd.2 .cntdot. 10-7 M) exerts anticholinesterase effect only. In concentrations 2 .cntdot. 10-6.sbd.2 .cntdot. 10-4 M, in addition to the anticholinesterase effect, it affects presynaptic membrane and inhibits postsynaptic membrane cholinoreceptors.

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Related references

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