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The effect of the cholin esterase inhibitor armin on the nerve muscle synapse of the frog sartorius muscle






Fiziologicheskii Zhurnal SSSR Imeni I M Sechenova 62(9): 1310-1316

The effect of the cholin esterase inhibitor armin on the nerve muscle synapse of the frog sartorius muscle

The organophosphorus cholinesterase inhibitor armin (2 .cntdot. 10-9.sbd.2 .cntdot. 10-4 M) prolonged postjunction potentials and in concentration 2 .cntdot. 10-9.sbd.2 .cntdot. 10-7 M increased the amplitude of miniature end-plate potentials (mepps) irreversibly. Armin (2 .cntdot. 10-6.sbd.2 .cntdot. 10-4 M) decreased the frequency of mepps and quantum content of epps. These parameters were increased again after washing. Thus, armin (2 .cntdot. 10-9.sbd.2 .cntdot. 10-7 M) exerts anticholinesterase effect only. In concentrations 2 .cntdot. 10-6.sbd.2 .cntdot. 10-4 M, in addition to the anticholinesterase effect, it affects presynaptic membrane and inhibits postsynaptic membrane cholinoreceptors.


Accession: 006656657



Related references

Danilov, A.F.; Skliarov, A.I., 1976: Effect of the cholinesterase inhibitor armin on meuromuscular synapse function of the frog sartorius muscle. The organophosphurus inhibitor of cholinesterases armin(2-10-9--2-10-4 M) prolonged postjunction potentials and in concentration 2-10-9--2-10-7 M increased the amplitude of miniature end-plate potentials (m. e. p. p. s and quantum content of e.p.p...

Sklyarov, A.I., 1975: The presynaptic action of the organo phosphorus cholin esterase inhibitor armine on the neuro muscular synapse of the frog sartorius muscle. The frog sartorius muscle-sciatic nerve preparation showed that armine in a concentration of 2 .cntdot. 10-6 M and higher decreased the frequency of the miniature end-plate potentials and the quantum composition of the end-plate potentials. The hi...

Skliarov, A.I., 1975: Presynaptic action of the organophosphorus cholinesterase inhibitor armin on the neuromuscular synapse of the frog sartorius muscle. Doklady Akademii Nauk SSSR 225(2): 454-456

Kuba, K.; Albuquerque, E.X.; Daly, J.; Barnard, E.A., 1974: A study of the irreversible cholin esterase inhibitor dfp on time course of end plate currents in frog sartorius muscle. Journal of Pharmacology and Experimental Therapeutics 189(2): 499-512

Csabai A.; Szoor A., 1971: Cholin esterase and esterase activity of frog sartorius muscle. Acta Physiologica Academiae Scientiarum Hungaricae 39(1-3): 172

Shumova I.A., 1968: Protection of muscle cholin esterase from irreversible inactivation by armine armin by administering some muscle relaxants. Farmakologiya i Toksikologiya (Moscow) 31(6): 721-725

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