The effect of the intake of a nitrosatable drug on the nitrosamine levels in human urine

Webb, K.S.; Wood, B.J.; Gough, T.A.

Journal of Analytical Toxicology 7(4): 181-184


ISSN/ISBN: 0146-4760
PMID: 6632801
DOI: 10.1093/jat/7.4.181
Accession: 006656904

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The combination of bacterial tract infection and administration of oxytetracycline poses a potential carcinogenic risk by the formation of N-nitrosodimethylamine. Experiments were described that demonstrated the presence of an N-nitroso compound in noninfected and infected human urine. An increase in the concentration of N-nitrosodimethylamine in the urine was usually associated with the administration of oxytetracycline.