The effects of postganglionic axotomy and nerve growth factor on the superior cervical ganglia of developing mice

Banks, B.E.; Walter, S.J.

Journal of Neurocytology 6(3): 287-297

1977


ISSN/ISBN: 0300-4864
PMID: 903795
DOI: 10.1007/bf01175192
Accession: 006666580

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Abstract
Sectioning of the 2 major outflows from the superior cervical ganglia in 2 wk mice results in a marked drop in the number of neurons within 1 wk of operation and a smaller drop over the following 2 wk. In animals receiving daily injections of nerve growth factor (NGF), the effect of axotomy is modified. One week after axotomy, the number of neurons in the axotomized ganglia is approximately the same in NGF treated animals as in control, sham operated ganglia. Over the next 2 wk the cell death that results from axotomy is no longer prevented by treatment with NGF. The normal, hyperplastic response to NGF appears to occur independently of the cell reaction caused by axotomy.

The effects of postganglionic axotomy and nerve growth factor on the superior cervical ganglia of developing mice