The efficiency of various immunization methods and schedules against newcastle disease immune state of chicken flocks after repeated drinking water and aerosol vaccinations with the la sota strain

Balla, L.; Szurop, I.; Toth, B.; Papocsi, L.

Acta Veterinaria Academiae Scientiarum Hungaricae 27(3): 253-264


ISSN/ISBN: 0001-7205
Accession: 006669885

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The immune state of chick flocks treated with La Sota vaccine in drinking water or by aerosol was studied by hemagglutination inhibition (HI) and laboratory challenge tests up to 10-13 wk of age. The HI tests were carried out by Takatsy's microtitration technique, using 8 HA units of B1 virus. Challenge was performed by s.c. administration of 106 median egg infective doses of virulent virus. The efficiency of drinking water vaccination was low when birds with maternal immunity were treated at 2-7 days of age. Immune response was also unsatisfactory in chicks treated with drinking water vaccine 3 times, at 4-6 days, 2-3 wk and 5 wk of age. Higher HI antibody levels and firmer protection were developed by aerosol vaccination at 1, 14 and 28 days of age. Drinking water vaccination at 10-14 days, 5 wk and 8 wk of age induced a satisfactory immune response in 17 large chick flocks. The mean values of the HI and challenge results obtained 14-21 days after the 1st, 2nd and 3rd vaccination were as follows: 77.5, 85.8 and 91.7% seropositivity; 1:4.4, 1:7.4 and 1:8.9 mean HI titers; 87.7, 92.4 and 95.7% full protection to challenge.